WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:Ribosome       ID:03010
C=92; O=71; E=0.41; R=173.35; rawP=1.07e-153; adjP=1.82e-152
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000177600 NA RPLP2 ribosomal protein, large, P2 6181 ENSG00000177600
2  ENSG00000213741 NA RPS29 ribosomal protein S29 6235 ENSG00000213741
3  ENSG00000156482 NA RPL30 ribosomal protein L30 6156 ENSG00000156482
4  ENSG00000083845 NA RPS5 ribosomal protein S5 6193 ENSG00000083845
5  ENSG00000198242 NA RPL23A ribosomal protein L23a 6147 ENSG00000198242
6  ENSG00000184779 NA RPS17 ribosomal protein S17 6218 ENSG00000184779
7  ENSG00000142676 NA RPL11 ribosomal protein L11 6135 ENSG00000142676
8  ENSG00000105193 NA RPS16 ribosomal protein S16 6217 ENSG00000105193
9  ENSG00000063177 NA RPL18 ribosomal protein L18 6141 ENSG00000063177
10  ENSG00000147403 NA RPL10 ribosomal protein L10 6134 ENSG00000147403
11  ENSG00000137154 NA RPS6 ribosomal protein S6 6194 ENSG00000137154
12  ENSG00000197756 NA RPL37A ribosomal protein L37a 6168 ENSG00000197756
13  ENSG00000171858 NA RPS21 ribosomal protein S21 6227 ENSG00000171858
14  ENSG00000231500 NA RPS18 ribosomal protein S18 6222 ENSG00000231500
15  ENSG00000110700 NA RPS13 ribosomal protein S13 6207 ENSG00000110700
16  ENSG00000162244 NA RPL29 ribosomal protein L29 6159 ENSG00000162244
17  ENSG00000221983 NA UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 7311 ENSG00000221983
18  ENSG00000136942 NA RPL35 ribosomal protein L35 11224 ENSG00000136942
19  ENSG00000118181 NA RPS25 ribosomal protein S25 6230 ENSG00000118181
20  ENSG00000071082 NA RPL31 ribosomal protein L31 6160 ENSG00000071082
21  ENSG00000172809 NA RPL38 ribosomal protein L38 6169 ENSG00000172809
22  ENSG00000177954 NA RPS27 ribosomal protein S27 6232 ENSG00000177954
23  ENSG00000105640 NA RPL18A ribosomal protein L18a 6142 ENSG00000105640
24  ENSG00000198755 NA RPL10A ribosomal protein L10a 4736 ENSG00000198755
25  ENSG00000170889 NA RPS9 ribosomal protein S9 6203 ENSG00000170889
26  ENSG00000168028 NA RPSA ribosomal protein SA 3921 ENSG00000168028
27  ENSG00000198034 NA RPS4X ribosomal protein S4, X-linked 6191 ENSG00000198034
28  ENSG00000145592 NA RPL37 ribosomal protein L37 6167 ENSG00000145592
29  ENSG00000182899 NA RPL35A ribosomal protein L35a 6165 ENSG00000182899
30  ENSG00000171863 NA RPS7 ribosomal protein S7 6201 ENSG00000171863
31  ENSG00000143947 NA RPS27A ribosomal protein S27a 6233 ENSG00000143947
32  ENSG00000164587 NA RPS14 ribosomal protein S14 6208 ENSG00000164587
33  ENSG00000137818 NA RPLP1 ribosomal protein, large, P1 6176 ENSG00000137818
34  ENSG00000188846 NA RPL14 ribosomal protein L14 9045 ENSG00000188846
35  ENSG00000116251 NA RPL22 ribosomal protein L22 6146 ENSG00000116251
36  ENSG00000149273 NA RPS3 ribosomal protein S3 6188 ENSG00000149273
37  ENSG00000149806 NA FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 2197 ENSG00000149806
38  ENSG00000008988 NA RPS20 ribosomal protein S20 6224 ENSG00000008988
39  ENSG00000142937 NA RPS8 ribosomal protein S8 6202 ENSG00000142937
40  ENSG00000115268 NA RPS15 ribosomal protein S15 6209 ENSG00000115268
41  ENSG00000140988 NA RPS2 ribosomal protein S2 6187 ENSG00000140988
42  ENSG00000174748 NA RPL15 ribosomal protein L15 6138 ENSG00000174748
43  ENSG00000122406 NA RPL5 ribosomal protein L5 6125 ENSG00000122406
44  ENSG00000142541 NA RPL13A ribosomal protein L13a 23521 ENSG00000142541
45  ENSG00000109475 NA RPL34 ribosomal protein L34 6164 ENSG00000109475
46  ENSG00000167526 NA RPL13 ribosomal protein L13 6137 ENSG00000167526
47  ENSG00000125691 NA RPL23 ribosomal protein L23 9349 ENSG00000125691
48  ENSG00000198918 NA RPL39 ribosomal protein L39 6170 ENSG00000198918
49  ENSG00000142534 NA RPS11 ribosomal protein S11 6205 ENSG00000142534
50  ENSG00000131469 NA RPL27 ribosomal protein L27 6155 ENSG00000131469
51  ENSG00000108298 NA RPL19 ribosomal protein L19 6143 ENSG00000108298
52  ENSG00000161970 NA RPL26 ribosomal protein L26 6154 ENSG00000161970
53  ENSG00000165502 NA RPL36AL ribosomal protein L36a-like 6166 ENSG00000165502
54  ENSG00000229117 NA RPL41 ribosomal protein L41 6171 ENSG00000229117
55  ENSG00000161016 NA RPL8 ribosomal protein L8 6132 ENSG00000161016
56  ENSG00000147604 NA RPL7 ribosomal protein L7 6129 ENSG00000147604
57  ENSG00000089009 NA RPL6 ribosomal protein L6 6128 ENSG00000089009
58  ENSG00000138326 NA RPS24 ribosomal protein S24 6229 ENSG00000138326
59  ENSG00000166441 NA RPL27A ribosomal protein L27a 6157 ENSG00000166441
60  ENSG00000089157 NA RPLP0 ribosomal protein, large, P0 6175 ENSG00000089157
61  ENSG00000130255 NA RPL36 ribosomal protein L36 25873 ENSG00000130255
62  ENSG00000145425 NA RPS3A ribosomal protein S3A 6189 ENSG00000145425
63  ENSG00000148303 NA RPL7A ribosomal protein L7a 6130 ENSG00000148303
64  ENSG00000197958 NA RPL12 ribosomal protein L12 6136 ENSG00000197958
65  ENSG00000144713 NA RPL32 ribosomal protein L32 6161 ENSG00000144713
66  ENSG00000108107 NA RPL28 ribosomal protein L28 6158 ENSG00000108107
67  ENSG00000134419 NA RPS15A ribosomal protein S15a 6210 ENSG00000134419
68  ENSG00000105372 NA RPS19 ribosomal protein S19 6223 ENSG00000105372
69  ENSG00000112306 NA RPS12 ribosomal protein S12 6206 ENSG00000112306
70  ENSG00000114391 NA RPL24 ribosomal protein L24 6152 ENSG00000114391
71  ENSG00000174444 NA RPL4 ribosomal protein L4 6124 ENSG00000174444


Database:KEGG pathway       Name:Spliceosome       ID:03040
C=127; O=7; E=0.57; R=12.38; rawP=1.77e-06; adjP=1.50e-05
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000204392 NA LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) 57819 ENSG00000204392
2  ENSG00000135486 NA HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 3178 ENSG00000135486
3  ENSG00000130520 NA LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) 25804 ENSG00000130520
4  ENSG00000171960 NA PPIH peptidylprolyl isomerase H (cyclophilin H) 10465 ENSG00000171960
5  ENSG00000100410 NA PHF5A PHD finger protein 5A 84844 ENSG00000100410
6  ENSG00000164167 NA LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) 11157 ENSG00000164167
7  ENSG00000146007 NA ZMAT2 zinc finger, matrin-type 2 153527 ENSG00000146007


Database:KEGG pathway       Name:Protein export       ID:03060
C=23; O=3; E=0.10; R=29.30; rawP=0.0001; adjP=0.0006
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000140612 NA SEC11A SEC11 homolog A (S. cerevisiae) 23478 ENSG00000140612
2  ENSG00000132432 NA SEC61G Sec61 gamma subunit 23480 ENSG00000132432
3  ENSG00000166562 NA SEC11C SEC11 homolog C (S. cerevisiae) 90701 ENSG00000166562


Database:KEGG pathway       Name:RNA degradation       ID:03018
C=71; O=4; E=0.32; R=12.65; rawP=0.0003; adjP=0.0013
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000204392 NA LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) 57819 ENSG00000204392
2  ENSG00000130520 NA LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) 25804 ENSG00000130520
3  ENSG00000164167 NA LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) 11157 ENSG00000164167
4  ENSG00000171311 NA EXOSC1 exosome component 1 51013 ENSG00000171311


Database:KEGG pathway       Name:Ribosome biogenesis in eukaryotes       ID:03008
C=80; O=4; E=0.36; R=11.23; rawP=0.0005; adjP=0.0017
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000115368 NA WDR75 WD repeat domain 75 84128 ENSG00000115368
2  ENSG00000105202 NA FBL fibrillarin 2091 ENSG00000105202
3  ENSG00000145912 NA NHP2 NHP2 ribonucleoprotein homolog (yeast) 55651 ENSG00000145912
4  ENSG00000055044 NA NOP58 NOP58 ribonucleoprotein homolog (yeast) 51602 ENSG00000055044


Database:KEGG pathway       Name:Pentose phosphate pathway       ID:00030
C=27; O=2; E=0.12; R=16.64; rawP=0.0064; adjP=0.0123
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000023697 NA DERA deoxyribose-phosphate aldolase (putative) 51071 ENSG00000023697
2  ENSG00000177156 NA TALDO1 transaldolase 1 6888 ENSG00000177156


Database:KEGG pathway       Name:Purine metabolism       ID:00230
C=162; O=4; E=0.72; R=5.55; rawP=0.0061; adjP=0.0123
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000165704 NA HPRT1 hypoxanthine phosphoribosyltransferase 1 3251 ENSG00000165704
2  ENSG00000178035 NA IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 3615 ENSG00000178035
3  ENSG00000066379 NA ZNRD1 zinc ribbon domain containing 1 30834 ENSG00000066379
4  ENSG00000115350 NA POLE4 polymerase (DNA-directed), epsilon 4, accessory subunit 56655 ENSG00000115350


Database:KEGG pathway       Name:Protein processing in endoplasmic reticulum       ID:04141
C=165; O=4; E=0.73; R=5.45; rawP=0.0065; adjP=0.0123
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000070010 NA UFD1L ubiquitin fusion degradation 1 like (yeast) 7353 ENSG00000070010
2  ENSG00000180879 NA SSR4 signal sequence receptor, delta 6748 ENSG00000180879
3  ENSG00000132432 NA SEC61G Sec61 gamma subunit 23480 ENSG00000132432
4  ENSG00000170142 NA UBE2E1 ubiquitin-conjugating enzyme E2E 1 7324 ENSG00000170142


Database:KEGG pathway       Name:RNA transport       ID:03013
C=151; O=4; E=0.67; R=5.95; rawP=0.0048; adjP=0.0123
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000092208 NA GEMIN2 gem (nuclear organelle) associated protein 2 8487 ENSG00000092208
2  ENSG00000115211 NA EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa 8890 ENSG00000115211
3  ENSG00000084623 NA EIF3I eukaryotic translation initiation factor 3, subunit I 8668 ENSG00000084623
4  ENSG00000100353 NA EIF3D eukaryotic translation initiation factor 3, subunit D 8664 ENSG00000100353


Database:KEGG pathway       Name:Nucleotide excision repair       ID:03420
C=44; O=2; E=0.20; R=10.21; rawP=0.0165; adjP=0.0280
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000134058 NA CDK7 cyclin-dependent kinase 7 1022 ENSG00000134058
2  ENSG00000115350 NA POLE4 polymerase (DNA-directed), epsilon 4, accessory subunit 56655 ENSG00000115350




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).